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Acomplia (Rimonabant)

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Diet pill Acomplia (Rimonabant) is a miraculous multifunctional pill that helps you short out obesity as well as smoking. Acomplia diet pills work on the Endocannabinoid system which controls appetite and energy expenditure (as well as the urge to smoke). This wonder pill selectively blocks some receptors in the Endocannabinoid system thus creating a better balance which in turn suppresses appetite and the longing to overeat.

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About Acomplia (Rimonabant):

Product Type: Weight Loss

Brand name: Acomplia Generic name: Rimonabant What is Acomplia? • Acomplia (rimonabant) is the first in a new class of therapeutic agents called Cannabinoid-1 Receptor Blockers (CB1). • Acomplia is used in the treatment of obesity and related conditions. How does Acomplia work? • Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism including adipose tissue the liver gastrointestinal tract and muscle1. • Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis. • CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2 3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance as well as glucose and lipid (or fat) metabolism. What is Acomplia used for? • Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. • Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease. • Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug. Does Acomplia also aid smoking cessation? • Acomplia has been studied by sanofi-aventis as an aid to smoking cessation based on studies for up to one year in over 6 500 smokers motivated to quit smoking. • Sanofi-aventis submitted a New Drug Application to the FDA which in turn issued a non approvable letter for Acomplia for use in smoking cessation. An approvable letter was however issued for Acomplia for use in weight management. Acomplia has just been approved in the European Union. Is Acomplia approved in the United States? • No. Sanofi is still awaiting U.S. marketing go-ahead which it has said could come by the end of this year. • U.S. health authorities have asked Sanofi for more information on Acomplia. • Acomplia received European Union marketing approval in June 2006. • The first launch will take place in Britain in July and be followed by launches in Denmark Ireland Germany Finland and Norway in the second half of this year according to Sanofi. What were the results of Acomplia Clinical trial studies? • In clinical studies Acomplia has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss4 5. • Approximately half of the observed improvement in HDL-cholesterol triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Acomplia 20mg was beyond that expected from weight loss alone6. What are the side-effects of Acomplia? • Side effects in the trial on Acomplia in obesity were vomiting and nausea forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo.

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Anti Depressants: Anafranil (Clomipramine HCI) Anafranil (Clomipramine HCI) is a tricyclic antidepressant used to treat depression and obsessive-compulsive disorder. Buy Anafranil (Clomipramine HCI) and other Anti Depressants products online at Medstore. About Anafranil (Clomipramine HCI): Product Type: Anti Depressants Brand name: Anafranil Generic name: Clomipramine HCI What is the most important information I should know about Anafranil? • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. What is Anafranil? • Anafranil is in a class of drugs called tricyclic antidepressants. Anafranil affects chemicals in the brain that may become unbalanced and cause obsessive-compulsive disorder. • Anafranil is used to relieve symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions. • Anafranil may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Before taking Anafranil tell your doctor if you have liver disease kidney disease asthma thyroid disease diabetes stomach or intestinal problems high blood pressure or heart disease had a heart attack in the last 6 weeks an enlarged prostate or difficulty urinating glaucoma or seizures. • You may not be able to take Anafranil or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above. • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • Anafranil is in the FDA pregnancy category C. This means that it is not known whether Anafranil will harm an unborn baby. Do not take Anafranil without first talking to your doctor if you are pregnant or could become pregnant during treatment. • Anafranil passes into breast milk and may affect a nursing baby. Do not take Anafranil without first talking to your doctor if you are breast-feeding a baby. How should I take Anafranil? • Take Anafranil exactly as directed by your doctor. If you do not understand these directions ask your pharmacist nurse or doctor to explain them to you. • Take each dose with a full glass (8 oz) of water. • Anafranil may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Store Anafranil at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a Anafranil overdose include seizures confusion drowsiness agitation hallucinations and low blood pressure (dizziness fatigue fainting). What should I avoid while taking Anafranil? • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • Do not stop taking Anafranil suddenly. This could cause symptoms such as nausea headache and malaise. What are the possible side effects of Anafranil? • If you experience any of the following serious side effects stop taking Anafranil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips face or tongue; or hives); seizures; a fast or irregular heartbeat; a heart attack; high blood pressure (blurred vision severe headache); difficulty urinating; or fever with increased sweating muscle stiffness or severe muscle weakness. • Other less serious side effects may be more likely to occur. Continue to take Anafranil and talk to your doctor if you experience drowsiness or dizziness; dry mouth and eyes; constipation; mild tremor; sweating; mild agitation weakness or headache; ringing in the ears; nausea; or loss of weight or appetite. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Anafranil may increase the effects of other drugs that cause drowsiness including other antidepressants alcohol antihistamines sedatives (used to treat insomnia) pain relievers anxiety medicines and muscle relaxants. Tell your doctor about all medicines that you are taking and do not take any other prescription or over-the-counter medicines without first talking to your doctor. • Drugs other than those listed here may also interact with Anafranil. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including herbal products. 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