Anti Depressants

Aromasin (Exemestane)

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Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation.

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About Aromasin (Exemestane):

Product Type: Other

Brand name: Aromasin Generic name: Exemestane What is Aromasin? Aromasin (exemestane) lowers estrogen levels in postmenopausal women which may slow the growth of certain types of breast tumors that need estrogen to grow. Aromasin is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex Soltamox) for 2 to 3 years. Aromasin may also be used for other purposes not listed. Important information about Aromasin Aromasin can cause harm to an unborn baby. Do not use this medicine without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control and tell your doctor if you become pregnant during treatment with Aromasin. You may need to take a pregnancy test before using Aromasin to make sure you are not pregnant. You also should not use Aromasin if you are breast-feeding a baby or if you are allergic to exemestane. Before using Aromasin tell your doctor if you have severe liver or kidney disease or if you have not yet completed menopause. If you have any of these conditions you may need a dose adjustment or special tests to safely take this medicine. You may need to keep taking this medicine for up to 5 years. Follow your doctor's instructions. Aromasin may not work as well if you take it together with hormone replacement medication or while using birth control pills or patches. Before taking Aromasin You should not use Aromasin if you are allergic to exemestane or if you are pregnant or breast-feeding. If you have any of these other conditions you may need a dose adjustment or special tests to safely use this medication: • liver disease; • kidney disease; or • not yet completed menopause. FDA pregnancy category D. Aromasin can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control and tell your doctor if you become pregnant during treatment. You may need to take a pregnancy test before using Aromasin to make sure you are not pregnant. It is not known whether exemestane passes into breast milk or if it could harm a nursing baby. Do not use Aromasin without telling your doctor if you are breast-feeding a baby. How should I take Aromasin? Take Aromasin exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label. Aromasin is usually taken once per day. You may need to keep taking take this medicine for up to 5 years. Follow your doctor's instructions. To be sure this medication is not causing harmful effects your blood may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor. Store this medicine at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include stomach pain nausea vomiting or blood in your stools. What should I avoid while taking Aromasin? Aromasin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Aromasin side effects Get emergency medical help if you have any of these signs of an allergic reaction to Aromasin: hives; difficulty breathing; swelling of your face lips tongue or throat. Call your doctor at once if you have any of these serious side effects: • swollen glands; • a bone fracture; • swelling in your hands or feet; • feeling short of breath even with mild exertion; or • chest pain sudden numbness or weakness sudden headache confusion problems with vision speech or balance. Less serious Aromasin side effects may include: • hot flashes; • anxiety; • upset stomach; • joint pain or stiffness; • weakness headache tired feeling; • depressed mood; • sleep problems (insomnia); or • increased sweating. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. What other drugs will affect Aromasin? Aromasin may not work as well if you take it together with hormone replacement medication or while using birth control pills or patches. Before you start taking Aromasin tell your doctor if you use any of the following drugs: • rifampin (Rifadin Rimactane Rifater); • St. John's wort; or • seizure medication such as carbamazepine (Carbatrol Tegretol) phenobarbital (Luminal Solfoton) or phenytoin (Dilantin). This list is not complete and there may be other drugs that can interact with Aromasin. Tell your doctor about all your prescription and over-the-counter medications vitamins minerals herbal products and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

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Anti Depressants: Anafranil (Clomipramine HCI) Anafranil (Clomipramine HCI) is a tricyclic antidepressant used to treat depression and obsessive-compulsive disorder. Buy Anafranil (Clomipramine HCI) and other Anti Depressants products online at Medstore. About Anafranil (Clomipramine HCI): Product Type: Anti Depressants Brand name: Anafranil Generic name: Clomipramine HCI What is the most important information I should know about Anafranil? • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. What is Anafranil? • Anafranil is in a class of drugs called tricyclic antidepressants. Anafranil affects chemicals in the brain that may become unbalanced and cause obsessive-compulsive disorder. • Anafranil is used to relieve symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions. • Anafranil may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Before taking Anafranil tell your doctor if you have liver disease kidney disease asthma thyroid disease diabetes stomach or intestinal problems high blood pressure or heart disease had a heart attack in the last 6 weeks an enlarged prostate or difficulty urinating glaucoma or seizures. • You may not be able to take Anafranil or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above. • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • Anafranil is in the FDA pregnancy category C. This means that it is not known whether Anafranil will harm an unborn baby. Do not take Anafranil without first talking to your doctor if you are pregnant or could become pregnant during treatment. • Anafranil passes into breast milk and may affect a nursing baby. Do not take Anafranil without first talking to your doctor if you are breast-feeding a baby. How should I take Anafranil? • Take Anafranil exactly as directed by your doctor. If you do not understand these directions ask your pharmacist nurse or doctor to explain them to you. • Take each dose with a full glass (8 oz) of water. • Anafranil may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Store Anafranil at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a Anafranil overdose include seizures confusion drowsiness agitation hallucinations and low blood pressure (dizziness fatigue fainting). What should I avoid while taking Anafranil? • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • Do not stop taking Anafranil suddenly. This could cause symptoms such as nausea headache and malaise. What are the possible side effects of Anafranil? • If you experience any of the following serious side effects stop taking Anafranil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips face or tongue; or hives); seizures; a fast or irregular heartbeat; a heart attack; high blood pressure (blurred vision severe headache); difficulty urinating; or fever with increased sweating muscle stiffness or severe muscle weakness. • Other less serious side effects may be more likely to occur. Continue to take Anafranil and talk to your doctor if you experience drowsiness or dizziness; dry mouth and eyes; constipation; mild tremor; sweating; mild agitation weakness or headache; ringing in the ears; nausea; or loss of weight or appetite. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Anafranil may increase the effects of other drugs that cause drowsiness including other antidepressants alcohol antihistamines sedatives (used to treat insomnia) pain relievers anxiety medicines and muscle relaxants. Tell your doctor about all medicines that you are taking and do not take any other prescription or over-the-counter medicines without first talking to your doctor. • Drugs other than those listed here may also interact with Anafranil. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including herbal products. 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