Anti Depressants

Cymbalta (Duloxetine)

Anti Depressants » Anti Depressants » Cymbalta (Duloxetine)

Cymbalta (Duloxetine) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression. It may also be used to treat certain types of nerve pain.

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About Cymbalta (Duloxetine):

Product Type: Anti Depressants

Brand name: Cymbalta Generic name: Duloxetine What is cymbalta? Cymbalta is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Cymbalta affects chemicals in the brain that may become unbalanced and cause depression. Cymbalta is used to treat major depressive disorder and general anxiety disorder. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy). Cymbalta may also be used for purposes other than those listed in this medication guide. What is the most important information I should know about cymbalta? Do not take cymbalta together with thioridazine (Mellaril) or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan) phenelzine (Nardil) rasagiline (Azilect) selegiline (Eldepryl Emsam) or tranylcypromine (Parnate). You must wait at least 14 days after stopping an MAOI before you can take cymbalta. After you stop taking cymbalta you must wait at least 5 days before you start taking an MAOI. You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication especially if you are under 18 years old. Talk with your doctor about this risk. While you are taking cymbalta you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment or whenever your dose is changed. In addition to you watching for changes in your own symptoms your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. Contact your doctor promptly if you have any of the following side effects especially if they are new symptoms or if they get worse: mood changes anxiety panic attacks trouble sleeping irritability agitation aggressiveness severe restlessness mania (mental and/or physical hyperactivity) thoughts of suicide or hurting yourself. Avoid using other medicines that make you sleepy (such as cold medicine pain medication muscle relaxers medicine for seizures other medication for depression or anxiety). They can add to sleepiness caused by cymbalta. Cymbalta can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. What should I discuss with my healthcare provider before taking cymbalta? Do not use cymbalta together with thioridazine (Mellaril) or an MAO inhibitor such as isocarboxazid (Marplan) tranylcypromine (Parnate) phenelzine (Nardil) rasagiline (Azilect) or selegiline (Eldepryl Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with cymbalta. You must wait at least 14 days after stopping an MAO inhibitor before you can take cymbalta. After you stop taking cymbalta you must wait at least 14 days before you start taking an MAOI. You must wait 5 days after stopping cymbalta before you can take an MAOI. Do not use this medication if you are allergic to cymbalta or if you have untreated or uncontrolled glaucoma. Before taking cymbalta tell your doctor if you are allergic to any drugs or if you have: • liver or kidney disease; • seizures or epilepsy; • bipolar disorder (manic depression); or • a history of drug abuse or suicidal thoughts. If you have any of these conditions you may not be able to use cymbalta or you may need a dosage adjustment or special tests during treatment. You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication especially if you are under 18 years old. Talk with your doctor about this risk. While you are taking cymbalta you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment or whenever your dose is changed. In addition to you watching for changes in your own symptoms your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. FDA pregnancy category C. Cymbalta may be harmful to an unborn baby and may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cymbalta can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more sensitive to the side effects of this medication. Do not give this medication to anyone under 18 years old without the advice of a doctor. How should I take cymbalta? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication. Try to take the medicine at the same time each day. Follow the directions on your prescription label. Do not crush chew break or open a delayed-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. It may take 4 weeks or longer for your symptoms improve. For best results keep using the medication as directed. Do not stop using cymbalta without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. Store cymbalta at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. However if it is almost time for the next regularly scheduled dose skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have taken too much of this medication. Symptoms of a cymbalta overdose may include nausea vomiting diarrhea agitation confusion hallucinations fast heart rate feeling light-headed or fainting. What should I avoid while taking cymbalta? Avoid drinking alcohol while taking cymbalta. Alcohol may increase the risk of damage to your liver. Avoid using other medicines that make you sleepy (such as cold medicine pain medication muscle relaxers medicine for seizures other medication for depression or anxiety). They can add to sleepiness caused by cymbalta. Cymbalta can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Cymbalta side effects Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face lips tongue or throat. Contact your doctor promptly if you have any of the following side effects especially if they are new symptoms or if they get worse: mood changes anxiety panic attacks trouble sleeping irritability agitation aggressiveness severe restlessness mania (mental and/or physical hyperactivity) thoughts of suicide or hurting yourself. Call your doctor at once if you have any of these serious side effects: • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes); • restlessness overactive reflexes hallucinations loss of coordination fainting coma; or • nausea vomiting diarrhea fever and fast heartbeat. Other less serious side effects are more likely to occur such as: • constipation; • drowsiness dizziness headache; • sleep problems (insomnia); • weight changes; • feeling anxious or nervous increased sweating; • sore throat; or • decreased sex drive impotence or difficulty having an orgasm. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect cymbalta? Talk to your doctor before taking any medicine for pain arthritis fever or swelling. This includes aspirin ibuprofen (Advil Motrin) naproxen (Aleve Naprosyn) diclofenac (Voltaren) indomethacin piroxicam (Feldene) nabumetone (Relafen) etodolac (Lodine) and others. Taking any of these drugs with cymbalta may cause you to bruise or bleed easily. Before taking cymbalta tell your doctor if you are using any of the following medicines: • cimetidine (Tagamet); • linezolid (Zyvox); • lithium (Lithobid Eskalith); • St. John's wort; • tramadol (Ultram); • tryptophan (sometimes called L-tryptophan); • a blood thinner such as warfarin (Coumadin); • almotriptan (Axert) frovatriptan (Frova) sumatriptan (Imitrex) naratriptan (Amerge) rizatriptan (Maxalt) or zolmitriptan (Zomig); or • any other antidepressants such as amitriptyline (Elavil) amoxapine (Ascendin) clomipramine (Anafranil) desipramine (Norpramin) escitalopram (Lexapro) fluoxetine (Prozac Sarafem) fluvoxamine (Luvox) imipramine (Janimine Tofranil) nortriptyline (Pamelor) paroxetine (Paxil) protriptyline (Vivactil) sertraline (Zoloft) trimipramine (Surmontil) or venlafaxine (Effexor). If you are using any of these drugs you may not be able to use cymbalta or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect cymbalta. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Anti Depressants: Anafranil (Clomipramine HCI) Anafranil (Clomipramine HCI) is a tricyclic antidepressant used to treat depression and obsessive-compulsive disorder. Buy Anafranil (Clomipramine HCI) and other Anti Depressants products online at Medstore. About Anafranil (Clomipramine HCI): Product Type: Anti Depressants Brand name: Anafranil Generic name: Clomipramine HCI What is the most important information I should know about Anafranil? • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. What is Anafranil? • Anafranil is in a class of drugs called tricyclic antidepressants. Anafranil affects chemicals in the brain that may become unbalanced and cause obsessive-compulsive disorder. • Anafranil is used to relieve symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions. • Anafranil may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Before taking Anafranil tell your doctor if you have liver disease kidney disease asthma thyroid disease diabetes stomach or intestinal problems high blood pressure or heart disease had a heart attack in the last 6 weeks an enlarged prostate or difficulty urinating glaucoma or seizures. • You may not be able to take Anafranil or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above. • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • Anafranil is in the FDA pregnancy category C. This means that it is not known whether Anafranil will harm an unborn baby. Do not take Anafranil without first talking to your doctor if you are pregnant or could become pregnant during treatment. • Anafranil passes into breast milk and may affect a nursing baby. Do not take Anafranil without first talking to your doctor if you are breast-feeding a baby. How should I take Anafranil? • Take Anafranil exactly as directed by your doctor. If you do not understand these directions ask your pharmacist nurse or doctor to explain them to you. • Take each dose with a full glass (8 oz) of water. • Anafranil may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Store Anafranil at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a Anafranil overdose include seizures confusion drowsiness agitation hallucinations and low blood pressure (dizziness fatigue fainting). What should I avoid while taking Anafranil? • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. If you experience drowsiness or dizziness avoid these activities. • Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. • Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Anafranil. • Grapefruit and grapefruit juice may interact with Anafranil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • Do not stop taking Anafranil suddenly. This could cause symptoms such as nausea headache and malaise. What are the possible side effects of Anafranil? • If you experience any of the following serious side effects stop taking Anafranil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips face or tongue; or hives); seizures; a fast or irregular heartbeat; a heart attack; high blood pressure (blurred vision severe headache); difficulty urinating; or fever with increased sweating muscle stiffness or severe muscle weakness. • Other less serious side effects may be more likely to occur. Continue to take Anafranil and talk to your doctor if you experience drowsiness or dizziness; dry mouth and eyes; constipation; mild tremor; sweating; mild agitation weakness or headache; ringing in the ears; nausea; or loss of weight or appetite. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Anafranil may increase the effects of other drugs that cause drowsiness including other antidepressants alcohol antihistamines sedatives (used to treat insomnia) pain relievers anxiety medicines and muscle relaxants. Tell your doctor about all medicines that you are taking and do not take any other prescription or over-the-counter medicines without first talking to your doctor. • Drugs other than those listed here may also interact with Anafranil. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including herbal products. 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