Anti Depressants

Mirapex (Pramipexol)

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Mirapex (Pramipexol) is a medication indicated for treating Parkinson's disease and restless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs. Mirapex (Pramipexol) has shown robust effects on pilot studies in bipolar disorder classified as a non-ergoline dopamine agonist.

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About Mirapex (Pramipexol):

Product Type: Other

Brand name: Mirapex Generic name: Pramipexol What is Mirapex (Pramipexol)? Mirapex has some of the same effects as a chemical called dopamine which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease. Mirapex is used to treat symptoms of Parkinson's disease such as stiffness tremors muscle spasms and poor muscle control. Mirapex is also used to treat restless legs syndrome (RLS). Mirapex may also be used for other purposes not listed in this medication guide. What is the most important information I should know about pramipexol? Some people taking pramipexol have fallen asleep during normal daytime activities such as working talking eating or driving. You may fall asleep suddenly even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. If you are unsure of how this medicine will affect you be careful if you drive or do anything that requires you to be awake and alert. If you are taking this medication for RLS tell your doctor if your symptoms get worse if they occur in the morning or earlier than usual in the evening or if you feel restless symptoms in your hands or arms. Do not stop using pramipexol without first talking to your doctor. You may need to use less and less before you stop the medication completely. Avoid getting up too fast from a sitting or lying position or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Cold or allergy medicine narcotic pain medicine sleeping pills muscle relaxers and medicine for seizures depression or anxiety can add to sleepiness caused by pramipexol. Tell your doctor if you regularly use any of these other medicines. Avoid drinking alcohol which can increase some of the side effects of pramipexol. Mirapex may cause hallucinations (the sensation of hearing or seeing something that is not there) most commonly among elderly people. Call your doctor if you have hallucinations. What should I discuss with my healthcare provider before taking pramipexol? Do not use this medication if you are allergic to pramipexol. Before using pramipexol tell your doctor if you are allergic to any drugs or if you have: • narcolepsy (a sleep disorder); • kidney disease; or • tremors (dyskinesia) or uncontrolled muscle movements. If you have any of these conditions you may need a dose adjustment or special tests to safely take pramipexol. Some people taking pramipexol have fallen asleep during normal daytime activities such as working talking eating or driving. You may fall asleep suddenly even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. If you are unsure of how this medicine will affect you be careful if you drive or do anything that requires you to be awake and alert. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Mirapex may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Mirapex may cause hallucinations (the sensation of hearing or seeing something that is not there) most commonly among elderly people. Call your doctor if you have hallucinations. How should I take pramipexol? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. The dose and timing of pramipexol in treating Parkinson's disease is different from the dose and timing in treating RLS. Follow the directions on your prescription label. Take each dose with a full glass of water. Mirapex can be taken with or without food. Take the medication with food if it upsets your stomach. If you are taking this medication for RLS tell your doctor if your symptoms get worse if they occur in the morning or earlier than usual in the evening or if you feel restless symptoms in your hands or arms. Do not stop using pramipexol without first talking to your doctor. You may need to use less and less before you stop the medication completely. Store pramipexol at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a pramipexol overdose are not known. What should I avoid while taking pramipexol? Mirapex can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Cold or allergy medicine narcotic pain medicine sleeping pills muscle relaxers and medicine for seizures depression or anxiety can add to sleepiness caused by pramipexol. Tell your doctor if you regularly use any of these other medicines. Avoid drinking alcohol which can increase some of the side effects of pramipexol. Avoid getting up too fast from a sitting or lying position or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Mirapex side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop taking pramipexol and call your doctor at once if you have any of these serious side effects: • extreme drowsiness falling asleep suddenly even after feeling alert; • hallucinations; • fever stiff muscles confusion sweating fast or uneven heartbeats; • nausea sweating feeling light-headed fainting; or • restless muscle movements in your eyes tongue jaw or neck. Less serious side effects may include: • constipation upset stomach loss of appetite; • dry mouth trouble swallowing; • urinating more often than usual; • mild drowsiness or sleepiness; • sleep problems (insomnia) unusual dreams; • amnesia forgetfulness thinking problems; • headache confusion weakness; • blurred vision; • joint pain muscle weakness; • swelling in your hands or feet; • runny or stuffy nose; • weight loss; or • impotence loss of interest in sex or trouble having an orgasm. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. What other drugs will affect pramipexol? Before taking pramipexol tell your doctor if you are using any of the following drugs: • amantadine (Symmetrel); • cimetidine (Tagamet); • diltiazem (Cardizem Cartia Dilacor Tiazac); • ranitidine (Zantac); • quinidine (Quinaglute Quinidex); • quinine(Qualaquin); • triamterine (Dyrenium); or • verapamil (Calan Covera Isoptin). This list is not complete and there may be other drugs that can interact with pramipexol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Anti Depressants: Anafranil (Clomipramine HCI) Anafranil (Clomipramine HCI) is a tricyclic antidepressant used to treat depression and obsessive-compulsive disorder. Buy Anafranil (Clomipramine HCI) and other Anti Depressants products online at Medstore. About Anafranil (Clomipramine HCI): Product Type: Anti Depressants Brand name: Anafranil Generic name: Clomipramine HCI What is the most important information I should know about Anafranil? • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. 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What should I discuss with my healthcare provider before taking Anafranil? • Do not take Anafranil if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan) phenelzine (Nardil) or tranylcypromine (Parnate) within the last 14 days. • Before taking Anafranil tell your doctor if you have liver disease kidney disease asthma thyroid disease diabetes stomach or intestinal problems high blood pressure or heart disease had a heart attack in the last 6 weeks an enlarged prostate or difficulty urinating glaucoma or seizures. • You may not be able to take Anafranil or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above. • While you are taking Anafranil you may need to be monitored for worsening symptoms of depression and/ or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking Anafranil. In patients younger than 18 years the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety panic attacks difficulty sleeping irritability hostility impulsivity severe restlessness and mania (mental and/ or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/ or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with Anafranil. Do not stop taking Anafranil. • Anafranil is in the FDA pregnancy category C. This means that it is not known whether Anafranil will harm an unborn baby. 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Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. • It may be 4 weeks or more before you start to feel better but do not stop taking Anafranil without first talking to your doctor. • Store Anafranil at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? • Seek emergency medical attention. • Symptoms of a Anafranil overdose include seizures confusion drowsiness agitation hallucinations and low blood pressure (dizziness fatigue fainting). What should I avoid while taking Anafranil? • Use caution when driving operating machinery or performing other hazardous activities. Anafranil may cause drowsiness or dizziness. 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What are the possible side effects of Anafranil? • If you experience any of the following serious side effects stop taking Anafranil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips face or tongue; or hives); seizures; a fast or irregular heartbeat; a heart attack; high blood pressure (blurred vision severe headache); difficulty urinating; or fever with increased sweating muscle stiffness or severe muscle weakness. • Other less serious side effects may be more likely to occur. Continue to take Anafranil and talk to your doctor if you experience drowsiness or dizziness; dry mouth and eyes; constipation; mild tremor; sweating; mild agitation weakness or headache; ringing in the ears; nausea; or loss of weight or appetite. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. 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